Telomere length is a prognostic factor in neuroblastoma

Plasma midkine level is a prognostic factor for human neuroblastoma.

Neuroblastoma is the third-most-common solid tumor of childhood. To date, no reliable blood marker for neuroblastoma has been established. The growth factor midkine is highly expressed in human carcinomas and its knockdown leads to tumor growth suppression in animal models. The present study evaluated the plasma midkine level in human neuroblastoma patients. Plasma samples were obtained from pa...

Is Leukocyte Telomere Length Related with Lung Cancer Risk?: A Meta-Analysis

Background: Epidemiological studies have probed the correlation between telomere length and the risk of lung cancer, but their findings are inconsistent in this regard.  The present meta-analysis study has been carried out to demonstrate the association between relative telomere length in peripheral blood leukocytes and the risk of lung cancer using an established Q-PCR technique. Methods:...

Intratumoral diversity of telomere length in individual neuroblastoma tumors

The purpose of the work was to investigate telomere length (TL) and mechanisms involved in TL maintenance in individual neuroblastoma (NB) tumors. Primary NB tumors from 102 patients, ninety Italian and twelve Spanish, diagnosed from 2000 to 2008 were studied. TL was investigated by quantitative fluorescence in situ hybridization (IQ-FISH) that allows to analyze individual cells in paraffin-emb...

Telomere Length as a Prognostic Factor for Overall Survival in Colorectal Cancer Patients.

BACKGROUND/AIMS The stabilization of telomere length has important roles in the carcinogenesis of colorectal cancer. A systemic review and meta-analysis of published studies was performed to assess the prognostic role of telomere length in colorectal cancer. METHODS Pubmed and Embase were searched for eligible studies on the association between telomere length and overall survival in colorect...

Telomere length as prognostic parameter in chronic lymphocytic leukemia